Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T/T222A) (307/309 > 99%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T) (308/309 > 99%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (L159M) (308/309 > 99%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (E166D) (308/309 > 99%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 610 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (T222A) (308/309 > 99%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 734 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (A162V) (308/309 > 99%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB B.MOAD GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 743 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-phosphoinositide dependent protein kinase-1 (310/310 = 100%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
University College Cork Curated by ChEMBL | Assay Description Inhibition of wild type PDK1 (unknown origin) | Bioorg Med Chem 26: 4209-4224 (2018) BindingDB Entry DOI: 10.7270/Q270843T | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-phosphoinositide-dependent protein kinase 1 (aa 51-359) (309/309 = 100%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Dundee | Assay Description In vitro PDK1 assay using purified enzyme, was incubated with substrate PDKtide, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P inco... | Structure 12: 215-26 (2004) Article DOI: 10.1016/j.str.2004.01.005 BindingDB Entry DOI: 10.7270/Q2SJ1HV2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-phosphoinositide dependent protein kinase-1 (310/310 = 100%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PCBioAssay | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) Article DOI: 10.1021/bi2002967 BindingDB Entry DOI: 10.7270/Q2FJ2F60 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-phosphoinositide dependent protein kinase-1 (310/310 = 100%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by ChEMBL | Assay Description Binding constant for PDPK1 kinase domain | Nat Biotechnol 29: 1046-51 (2011) Article DOI: 10.1038/nbt.1990 BindingDB Entry DOI: 10.7270/Q25D8S70 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
3-phosphoinositide dependent protein kinase-1 (310/310 = 100%)† (Homo sapiens (Human)) | BDBM17055![]() ((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a |
Ambit Biosciences Curated by ChEMBL | Assay Description Binding constant for full-length PDPK1 | Nat Biotechnol 26: 127-32 (2008) Article DOI: 10.1038/nbt1358 BindingDB Entry DOI: 10.7270/Q2TT4RX2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |