Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate Reductase (DHFR) (205/205 = 100%)† (Pneumocystis carinii) | BDBM50058401![]() (2,4-Diamino-5-[4-chloro-3-[3-[2-(acetyloxy)ethyl]-...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham Curated by ChEMBL | Assay Description In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductase | J Med Chem 40: 1886-93 (1997) Article DOI: 10.1021/jm970050n BindingDB Entry DOI: 10.7270/Q2RJ4HK9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |