Affinity Data by PDB ID

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PDB code 1VYZ

Identical Ligands in BindingDB

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 2 (298/298 = 100%)^† (Homo sapiens (Human))	BDBM7127 (3-Benzamidoaminopyrazole deriv. 4 \| CHEMBL324942 \|...) Show SMILES O=C(Nc1cc(n[nH]1)C1CC1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Chemical Biology (CSIR) Curated by ChEMBL					Assay Description Inhibition of CDK2/Cyclin A (unknown origin)				Eur J Med Chem 43: 2807-18 (2008) Article DOI: 10.1016/j.ejmech.2007.10.016 BindingDB Entry DOI: 10.7270/Q2MP5324
Institute of Chemical Biology (CSIR) Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-Dependent Kinase 2 (CDK2) (298/298 = 100%)^† (Homo sapiens (Human))	BDBM7127 (3-Benzamidoaminopyrazole deriv. 4 \| CHEMBL324942 \|...) Show SMILES O=C(Nc1cc(n[nH]1)C1CC1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	7.4	22
Pharmacia Italia					Assay Description The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...				J Med Chem 47: 3367-80 (2004) Article DOI: 10.1021/jm031145u BindingDB Entry DOI: 10.7270/Q2RX998G
Pharmacia Italia					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output