TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit
Curated by ChEMBL
Vrije Universiteit
Curated by ChEMBL
Affinity DataIC50: 158nMAssay Description:Inhibition of PDE4 in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit
Curated by ChEMBL
Vrije Universiteit
Curated by ChEMBL
Affinity DataIC50: 158nMAssay Description:inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)(Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: 390nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Vrije Universiteit
Curated by ChEMBL
Vrije Universiteit
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:In vitro inhibition of bovine smooth muscle phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human PDE4D expressed in Escherichia coli assessed as increase in cAMP levels after 60 mins by BIOMOLGREEN dye-based assayMore data for this Ligand-Target Pair