Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase (BACE) (389/389 = 100%)† (Homo sapiens (Human)) | BDBM16271![]() ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB PubMed | 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human brain BACE1 | J Med Chem 56: 4156-80 (2013) BindingDB Entry DOI: 10.7270/Q2KK9FQZ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Beta-secretase 1 (389/389 = 100%)† (Homo sapiens (Human)) | BDBM16271![]() ((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 25.1 | -45.1 | n/a | n/a | n/a | n/a | n/a | 4.5 | 37 |
University of Illinois at Chicago | Assay Description Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record... | Bioorg Med Chem Lett 15: 15-20 (2005) Article DOI: 10.1016/j.bmcl.2004.10.084 BindingDB Entry DOI: 10.7270/Q2ZC814B | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |