Affinity Data by PDB ID

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PDB code 1ZKL

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphodiesterase 7 (353/353 = 100%)^† (Homo sapiens (Human))	BDBM50027176 (2-Acetoxy-Benzoic Acid \| 3-Isobutyl-Methylxanthine...) Show SMILES CC(C)Cn1c2[nH]cnc2c(=O)n(C)c1=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PDB Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Inhibition of human phosphodiesterase 7				J Med Chem 48: 3449-62 (2005) Article DOI: 10.1021/jm040217u BindingDB Entry DOI: 10.7270/Q21G0N2H
Monash University (Parkville Campus) Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
3',5'-cyclic phosphodiesterase (353/353 = 100%)^† (Homo sapiens (Human))	BDBM50027176 (2-Acetoxy-Benzoic Acid \| 3-Isobutyl-Methylxanthine...) Show SMILES CC(C)Cn1c2[nH]cnc2c(=O)n(C)c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	8.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) BindingDB Entry DOI: 10.7270/Q2TB19K7
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
3',5'-cyclic phosphodiesterase (353/353 = 100%)^† (Homo sapiens (Human))	BDBM50027176 (2-Acetoxy-Benzoic Acid \| 3-Isobutyl-Methylxanthine...) Show SMILES CC(C)Cn1c2[nH]cnc2c(=O)n(C)c1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase DrugBank PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	8.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) BindingDB Entry DOI: 10.7270/Q2XD1496
Jagiellonian University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output