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Found 3 Enz. Inhib. hit(s) for PDB: 2AFW
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM7949(Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl...)
Affinity DataKi:  1.70E+3nM ΔG°:  -32.9kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM7949(Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl...)
Affinity DataKi:  5.75E+3nM ΔG°:  -29.9kJ/molepH: 8.0 T: 2°CAssay Description:The testing for the inhibition activities of imidazole derivatives and cacodylate on gQC and sQC was evaluated at 25 C using the fluorescent substrat...More data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
Academia Sinica

LigandPNGBDBM7949(Imidazole C-4(5) deriv. 1 | N-[2-(1H-Imidazol-4-yl...)
Affinity DataKi:  1.70E+4nM ΔG°:  -27.7kJ/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair