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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Monoamine oxidase (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Center Curated by ChEMBL | Assay Description Inhibition of bovine brain MAOA using kinuramine as substrate preincubated for 30 mins prior to substrate addition measured after 30 mins by fluorome... | J Med Chem 55: 10424-36 (2012) Article DOI: 10.1021/jm301014y BindingDB Entry DOI: 10.7270/Q2G73FWJ | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibitory activity against monoamine oxidase A in isolated bovine brain mitochondria | J Med Chem 46: 917-20 (2003) Article DOI: 10.1021/jm0256124 BindingDB Entry DOI: 10.7270/Q20V8C52 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine Oxidase Type A (MAO-A) (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 54 | -43.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 38 |
Universita di Roma La Sapienza | Assay Description MAO A and MAO B activities were determined spectrophotometrically using kinuramine as substrates. Fluorimetric measurements were recorded with a Perk... | J Med Chem 50: 922-31 (2007) Article DOI: 10.1021/jm060882y BindingDB Entry DOI: 10.7270/Q2GH9G61 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Università di Roma Curated by ChEMBL | Assay Description Inhibition of bovine brain mitochondrial MAO-A by fluorometric assay | Bioorg Med Chem 16: 9729-40 (2008) Article DOI: 10.1016/j.bmc.2008.09.072 BindingDB Entry DOI: 10.7270/Q20001ZK | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hacettepe University Curated by ChEMBL | Assay Description Inhibition of MAO-A in rat liver homogenate after 60 mins by Lineweaver-Burk plot | Bioorg Med Chem 17: 675-89 (2009) Article DOI: 10.1016/j.bmc.2008.11.068 BindingDB Entry DOI: 10.7270/Q2BG2NWT | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.00490 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of human monoamine oxidase A | Bioorg Med Chem 18: 7675-99 (2010) Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
General Hospital of PLA Curated by ChEMBL | Assay Description Inhibition of MAO-A in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay | Bioorg Med Chem Lett 22: 3343-8 (2012) Article DOI: 10.1016/j.bmcl.2012.02.090 BindingDB Entry DOI: 10.7270/Q2JW8FWM | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
R-Tech Ueno, Ltd. US Patent | Assay Description The compounds of the present invention obtained in the Production Examples were examined for the inhibitory effect on human monoamineoxydase enzymes ... | US Patent US9603833 (2017) Article DOI: 10.1021/jm950576c BindingDB Entry DOI: 10.7270/Q2W37ZCW | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro Inhibitory activity of Monoamine oxidase at rat hyphalamic mitochondrial 5-HT by displacing 2.5 uM of [14C]5-HT (serotonin) | J Med Chem 26: 1036-42 (1983) Article DOI: 10.1021/jm00361a017 BindingDB Entry DOI: 10.7270/Q2K076FV | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Paris 7 Curated by ChEMBL | Assay Description In vitro inhibitory activity on rat brain by monoamine oxidase A (MAO-A) | J Med Chem 36: 1157-67 (1993) Article DOI: 10.1021/jm00061a006 BindingDB Entry DOI: 10.7270/Q2765FZP | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA expressed in insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectrophotometr... | Bioorg Med Chem Lett 22: 7367-70 (2012) Article DOI: 10.1016/j.bmcl.2012.10.070 BindingDB Entry DOI: 10.7270/Q2CN7526 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate after 30 mins by fluorescence spectrophotometry | Bioorg Med Chem 24: 2342-51 (2016) Article DOI: 10.1016/j.bmc.2016.04.012 BindingDB Entry DOI: 10.7270/Q21N8316 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected High 5 insect cells using kynuramine as substrate incubated for 30 mins by sp... | Bioorg Med Chem 25: 1030-1041 (2017) Article DOI: 10.1016/j.bmc.2016.12.013 BindingDB Entry DOI: 10.7270/Q2PR7XZS | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate measured after 30 mins by fluorescence assay | Bioorg Med Chem 25: 714-726 (2017) Article DOI: 10.1016/j.bmc.2016.11.048 BindingDB Entry DOI: 10.7270/Q21C1ZVW | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluor... | Eur J Med Chem 126: 762-775 (2017) Article DOI: 10.1016/j.ejmech.2016.12.009 BindingDB Entry DOI: 10.7270/Q2NG4SW1 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorimetric ... | Bioorg Med Chem 25: 1997-2009 (2017) Article DOI: 10.1016/j.bmc.2017.02.027 BindingDB Entry DOI: 10.7270/Q2Q81GBJ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase A (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University Curated by ChEMBL | Assay Description Inhibition of bovine brain mitochondria MAO-A using serotonin substrate after 60 mins by fluorimetric method | Bioorg Med Chem 23: 3574-85 (2015) Article DOI: 10.1016/j.bmc.2015.04.021 BindingDB Entry DOI: 10.7270/Q28K7BVZ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University Curated by ChEMBL | Assay Description Inhibition of MAO-A in rat liver mitochondria using serotonin as substrate preincubated with enzyme for 60 mins prior to substrate addition | Bioorg Med Chem Lett 25: 70-4 (2015) Article DOI: 10.1016/j.bmcl.2014.11.007 BindingDB Entry DOI: 10.7270/Q24F1SGH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Jena Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA | J Med Chem 58: 6710-5 (2015) Article DOI: 10.1021/acs.jmedchem.5b00958 BindingDB Entry DOI: 10.7270/Q2QZ2CRZ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University Curated by ChEMBL | Assay Description Inhibition of bovine brain MAO-A preincubated for 60 mins before substrate addition by fluorimetric method | Eur J Med Chem 93: 308-20 (2015) Article DOI: 10.1016/j.ejmech.2015.02.020 BindingDB Entry DOI: 10.7270/Q2VH5QJ9 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Assiut University Curated by ChEMBL | Assay Description Inhibition of bovine brain mitochondria MAO-A by spectrofluorimetry | Eur J Med Chem 93: 481-91 (2015) Article DOI: 10.1016/j.ejmech.2015.02.039 BindingDB Entry DOI: 10.7270/Q2FX7C5D | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University Curated by ChEMBL | Assay Description Inhibition of MAOA by spectrophotometry | Eur J Med Chem 45: 4479-89 (2010) Article DOI: 10.1016/j.ejmech.2010.07.008 BindingDB Entry DOI: 10.7270/Q21G0N86 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana Curated by ChEMBL | Assay Description Inhibition of human recombinant microsomal MAO-A expressed in baculovirus-infected insect cells using p-tyramine as substrate preincubated for 15 min... | Bioorg Med Chem 25: 633-645 (2017) Article DOI: 10.1016/j.bmc.2016.11.032 BindingDB Entry DOI: 10.7270/Q2HH6N2G | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (464/527 = 88%)† (Bos taurus) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Manipal College of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of MAO-A in bovine brain mitochondria using serotonin as substrate preincubated for 30 mins measured after 30 mins by spectrofluorimetric ... | Bioorg Med Chem Lett 25: 5281-5 (2015) Article DOI: 10.1016/j.bmcl.2015.09.048 BindingDB Entry DOI: 10.7270/Q2M90BH5 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Santiago de Compostela 15782 Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyra... | Eur J Med Chem 46: 5838-51 (2011) Article DOI: 10.1016/j.ejmech.2011.09.045 BindingDB Entry DOI: 10.7270/Q2VD6ZVK | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay | Bioorg Med Chem 18: 1273-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.029 BindingDB Entry DOI: 10.7270/Q2X63N2Z | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-A using p-tyramine substrate preincubated for 15 mins before substrate addition measured after 20 mins by fluores... | Eur J Med Chem 62: 745-53 (2013) Article DOI: 10.1016/j.ejmech.2013.01.039 BindingDB Entry DOI: 10.7270/Q2C82BN6 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A using p-tyramine as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by fluor... | Bioorg Med Chem 23: 3722-9 (2015) Article DOI: 10.1016/j.bmc.2015.04.009 BindingDB Entry DOI: 10.7270/Q2S46TQR | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA assessed as H2O2 production by Amplex Red reagent-based assay | J Med Chem 55: 8483-92 (2012) Article DOI: 10.1021/jm300978h BindingDB Entry DOI: 10.7270/Q29Z962V | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate incubated for 15 mins prior to substrate... | Eur J Med Chem 58: 405-17 (2012) Article DOI: 10.1016/j.ejmech.2012.10.032 BindingDB Entry DOI: 10.7270/Q20G3M75 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected insect BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-t... | J Med Chem 53: 6516-20 (2010) Article DOI: 10.1021/jm100120s BindingDB Entry DOI: 10.7270/Q26H4HNW | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento Farmaco Chimico Tecnologico Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected BTI insect cells assessed as hydrogen peroxide production after 15 mins by Amp... | Eur J Med Chem 45: 4490-8 (2010) Article DOI: 10.1016/j.ejmech.2010.07.009 BindingDB Entry DOI: 10.7270/Q2FT8M7J | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of human MAOA by fluorimetry | Bioorg Med Chem 18: 5715-23 (2010) Article DOI: 10.1016/j.bmc.2010.06.007 BindingDB Entry DOI: 10.7270/Q25D8S19 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Roma Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA | Eur J Med Chem 45: 800-4 (2010) Article DOI: 10.1016/j.ejmech.2009.11.003 BindingDB Entry DOI: 10.7270/Q2CR5TH5 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Santiago de Compostela 15782 Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA by fluorimetric method | J Med Chem 51: 6740-51 (2008) Article DOI: 10.1021/jm800656v BindingDB Entry DOI: 10.7270/Q2NV9J3H | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita` La Sapienza di Roma Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorim... | J Med Chem 54: 2155-64 (2011) Article DOI: 10.1021/jm1013709 BindingDB Entry DOI: 10.7270/Q2902435 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Quaid-i-Azam University | Assay Description The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu... | Bioorg Chem 70: 17-26 (2017) Article DOI: 10.1016/j.bioorg.2016.11.004 BindingDB Entry DOI: 10.7270/Q2WM1C7Z | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza - Universit£ di Roma Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BT1-TN-5B1-4 cells assessed as inhibition of production of hydrogen peroxide ... | Eur J Med Chem 59: 91-100 (2013) Article DOI: 10.1016/j.ejmech.2012.11.006 BindingDB Entry DOI: 10.7270/Q2T43VFR | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Universita degli Studi di Roma La Sapienza | Assay Description The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide... | J Med Chem 52: 2818-24 (2009) Article DOI: 10.1021/jm801590u BindingDB Entry DOI: 10.7270/Q2X63K8T | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus-infected BTI-TN-5B1-4 cell microsomes assessed as decrease in H2O2 production using p-... | Bioorg Med Chem 22: 2887-95 (2014) Article DOI: 10.1016/j.bmc.2014.03.042 BindingDB Entry DOI: 10.7270/Q2C53NCP | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Roma Curated by ChEMBL | Assay Description Inhibition of human recombinant microsomal MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate assessed as reduc... | Eur J Med Chem 117: 292-300 (2016) Article DOI: 10.1016/j.ejmech.2016.03.081 BindingDB Entry DOI: 10.7270/Q2JW8GSP | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Roma La Sapienza P.le Aldo Moro Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BT1 cells | Bioorg Med Chem Lett 20: 6479-82 (2010) Article DOI: 10.1016/j.bmcl.2010.09.061 BindingDB Entry DOI: 10.7270/Q2HM59QH | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi Magna Gr£cia di Catanzaro Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as inhibition of hydrogen peroxide product... | Eur J Med Chem 48: 284-95 (2012) Article DOI: 10.1016/j.ejmech.2011.12.027 BindingDB Entry DOI: 10.7270/Q2JS9QW8 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI cells using p-tyramine as substrate after 15 mins by Amplex Red-based flu... | Eur J Med Chem 108: 542-52 (2016) Article DOI: 10.1016/j.ejmech.2015.12.026 BindingDB Entry DOI: 10.7270/Q2GX4DFK | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratorio de Qu�mica M�dica, (IQOG, CSIC) Curated by ChEMBL | Assay Description Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 15 mins | J Med Chem 57: 10455-63 (2014) Article DOI: 10.1021/jm501501a BindingDB Entry DOI: 10.7270/Q2WS8VX3 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"Aldo Moro" Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A using kynuramine substrate by spectrophotometric assay | J Med Chem 58: 5561-78 (2015) Article DOI: 10.1021/acs.jmedchem.5b00599 BindingDB Entry DOI: 10.7270/Q26T0PCZ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Chimica e Tecnologie del Farmaco Universit£ degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyra... | Bioorg Med Chem 18: 5063-70 (2010) Article DOI: 10.1016/j.bmc.2010.05.070 BindingDB Entry DOI: 10.7270/Q22F7PD1 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Magna Graecia di Catanzaro Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A assessed as inhibition of production of hydrogen peroxide after 15 mins by Amplex Red fluorimetric method | Bioorg Med Chem Lett 20: 2709-12 (2010) Article DOI: 10.1016/j.bmcl.2010.03.081 BindingDB Entry DOI: 10.7270/Q22V2G80 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana... | Bioorg Med Chem Lett 22: 4926-9 (2012) Article DOI: 10.1016/j.bmcl.2012.06.058 BindingDB Entry DOI: 10.7270/Q21Z45GF | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Sichuan University | Assay Description Recombinant human MAO-A and MAO-B (5 mg/mL) were purchased from Sigma-Aldrich, pre-aliquoted and stored at -80 °C. Solutions of test compounds we... | Bioorg Chem 71: 305-314 (2017) Article DOI: 10.1016/j.bioorg.2017.02.016 BindingDB Entry DOI: 10.7270/Q2X9295T | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence assay | Bioorg Med Chem Lett 27: 718-722 (2017) Article DOI: 10.1016/j.bmcl.2017.01.050 BindingDB Entry DOI: 10.7270/Q2JM2CX6 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology Curated by ChEMBL | Assay Description Inhibition of recombinant human MAOA using p-tyramine as substrate after 30 mins by Amplex red based spectrophotometric analysis | Bioorg Med Chem 23: 6486-96 (2015) Article DOI: 10.1016/j.bmc.2015.08.012 BindingDB Entry DOI: 10.7270/Q2MK6FPP | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Parma Curated by ChEMBL | Assay Description Inhibition of human MAOA after 1 hr by luminescence assay | J Med Chem 56: 1247-61 (2013) Article DOI: 10.1021/jm301686s BindingDB Entry DOI: 10.7270/Q2SB472H | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA using p-tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by horse... | Eur J Med Chem 121: 864-879 (2016) Article DOI: 10.1016/j.ejmech.2015.10.001 BindingDB Entry DOI: 10.7270/Q2B27X8T | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm S.p.A US Patent | Assay Description Inhibitory activity of compounds was evaluated by a homogeneous luminescent method, the MAO-Glo Assay (Promega), measuring the monoamine oxidase acti... | US Patent US8633208 (2014) BindingDB Entry DOI: 10.7270/Q23J3BMD | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University Curated by ChEMBL | Assay Description Inhibition of MAO-A in rat liver homogenate using [14C]-5HT as substrate preincubated for 30 mins followed by substrate addition measured after 20 mi... | Eur J Med Chem 80: 543-61 (2014) Article DOI: 10.1016/j.ejmech.2014.04.078 BindingDB Entry DOI: 10.7270/Q2BK1DWK | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 30.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in insect cells assessed as inhibition of kynuramine oxidation after 30 mins by fluorescence assay | J Med Chem 54: 7023-9 (2011) Article DOI: 10.1021/jm200710b BindingDB Entry DOI: 10.7270/Q2765FQJ | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University Curated by ChEMBL | Assay Description Inhibition of recombinant human microsomal MAO-A expressed in baculovirus-infected insect cells using p-tyramine as substrate assessed as H2O2 produc... | Bioorg Med Chem 24: 1741-8 (2016) Article DOI: 10.1016/j.bmc.2016.02.045 BindingDB Entry DOI: 10.7270/Q2T72K99 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro Inhibitory activity of Monoamine oxidase at rat hyphalamic mitochondrial PEA by displacing 2.5 uM of [14C]PEA (phenethylamine) | J Med Chem 26: 1036-42 (1983) Article DOI: 10.1021/jm00361a017 BindingDB Entry DOI: 10.7270/Q2K076FV | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Technology Curated by ChEMBL | Assay Description Inhibition of MAOA in rat liver homogenates preincubated for 60 mins | Bioorg Med Chem Lett 18: 6362-8 (2008) Article DOI: 10.1016/j.bmcl.2008.10.084 BindingDB Entry DOI: 10.7270/Q2GT5N1F | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hacettepe University Curated by ChEMBL | Assay Description Inhibition of MAO-A in rat liver homogenate after 60 mins by residual activity plot | Bioorg Med Chem 17: 675-89 (2009) Article DOI: 10.1016/j.bmc.2008.11.068 BindingDB Entry DOI: 10.7270/Q2BG2NWT | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hacettepe University Curated by ChEMBL | Assay Description Inhibition of rat liver MAOA after 60 mins pre-incubation | Bioorg Med Chem 15: 5775-86 (2007) Article DOI: 10.1016/j.bmc.2007.06.004 BindingDB Entry DOI: 10.7270/Q2JH3N0R | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology Curated by ChEMBL | Assay Description Inhibition of recombinant human MAOA using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate additio... | Eur J Med Chem 103: 185-90 (2015) Article DOI: 10.1016/j.ejmech.2015.08.055 BindingDB Entry DOI: 10.7270/Q29C7070 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A using p-tyramine as substrate assessed as production of H2O2 incubated for 15 mins prior to substrate addition ... | Bioorg Med Chem 23: 515-25 (2015) Article DOI: 10.1016/j.bmc.2014.12.010 BindingDB Entry DOI: 10.7270/Q2R2132N | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of human recombinant MAOA | J Med Chem 51: 4874-80 (2008) Article DOI: 10.1021/jm800132g BindingDB Entry DOI: 10.7270/Q27P8Z5J | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Amine oxidase [flavin-containing] A (527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Roma Sapienza Curated by ChEMBL | Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramin... | Eur J Med Chem 46: 4846-52 (2011) Article DOI: 10.1016/j.ejmech.2011.07.017 BindingDB Entry DOI: 10.7270/Q2QV3MXF | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Monoamine oxidase (459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against rat brain mitochondrial Monoamine oxidase | J Med Chem 28: 186-93 (1985) Article DOI: 10.1021/jm00380a007 BindingDB Entry DOI: 10.7270/Q26M3910 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
