Found 86 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Padova
Curated by ChEMBL
| Assay Description Irreversible inhibition of recombinant human MAO-A expressed in baculovirus infected BT1 cells using p-tyramine as substrate by Lineweaver-Burk plot ... |
Eur J Med Chem 70: 88-101 (2013)
BindingDB Entry DOI: 10.7270/Q2T156MV |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine Oxidase Type A (MAO-A)
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| 54 | -43.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 38 |
Sapienza University of Rome
| Assay Description MAO A and MAO B activities were determined spectrophotometrically using kinuramine as substrates. Fluorimetric measurements were recorded with a Perk... |
J Med Chem 50: 922-31 (2007)
Article DOI: 10.1021/jm060882y BindingDB Entry DOI: 10.7270/Q2GH9G61 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibitory activity against monoamine oxidase A in isolated bovine brain mitochondria |
J Med Chem 46: 917-20 (2003)
Article DOI: 10.1021/jm0256124 BindingDB Entry DOI: 10.7270/Q20V8C52 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of bovine brain mitochondrial MAO-A by fluorometric assay |
Bioorg Med Chem 16: 9729-40 (2008)
Article DOI: 10.1016/j.bmc.2008.09.072 BindingDB Entry DOI: 10.7270/Q20001ZK |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Center
Curated by ChEMBL
| Assay Description Inhibition of bovine brain MAOA using kinuramine as substrate preincubated for 30 mins prior to substrate addition measured after 30 mins by fluorome... |
J Med Chem 55: 10424-36 (2012)
Article DOI: 10.1021/jm301014y BindingDB Entry DOI: 10.7270/Q2G73FWJ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hacettepe University
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in rat liver homogenate after 60 mins by Lineweaver-Burk plot |
Bioorg Med Chem 17: 675-89 (2009)
Article DOI: 10.1016/j.bmc.2008.11.068 BindingDB Entry DOI: 10.7270/Q2BG2NWT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 0.00490 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Inhibition of human monoamine oxidase A |
Bioorg Med Chem 18: 7675-99 (2010)
Article DOI: 10.1016/j.bmc.2010.07.034 BindingDB Entry DOI: 10.7270/Q2DF6S69 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 0.420 | n/a | n/a | n/a | n/a | n/a | n/a |
General Hospital of PLA
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay |
Bioorg Med Chem Lett 22: 3343-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.090 BindingDB Entry DOI: 10.7270/Q2JW8FWM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
R-Tech Ueno, Ltd.
US Patent
| Assay Description The compounds of the present invention obtained in the Production Examples were examined for the inhibitory effect on human monoamineoxydase enzymes ... |
US Patent US9603833 (2017)
BindingDB Entry DOI: 10.7270/Q2W37ZCW |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro Inhibitory activity of Monoamine oxidase at rat hyphalamic mitochondrial 5-HT by displacing 2.5 uM of [14C]5-HT (serotonin) |
J Med Chem 26: 1036-42 (1983)
Article DOI: 10.1021/jm00361a017 BindingDB Entry DOI: 10.7270/Q2K076FV |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of the Western Cape
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A assessed as reduction in 4-hydroxyquinolone production using kynuramine as substrate after 20 mins by fluoresce... |
Eur J Med Chem 125: 853-864 (2017)
Article DOI: 10.1016/j.ejmech.2016.09.041 BindingDB Entry DOI: 10.7270/Q2BP057T |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Paris 7
Curated by ChEMBL
| Assay Description In vitro inhibitory activity on rat brain by monoamine oxidase A (MAO-A) |
J Med Chem 36: 1157-67 (1993)
Article DOI: 10.1021/jm00061a006 BindingDB Entry DOI: 10.7270/Q2765FZP |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using tyramine as substrate preincubated for 1 hr f... |
J Med Chem 61: 7043-7064 (2018)
BindingDB Entry DOI: 10.7270/Q2VT1VSP |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
North-West University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA expressed in insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectrophotometr... |
Bioorg Med Chem Lett 22: 7367-70 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.070 BindingDB Entry DOI: 10.7270/Q2CN7526 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate measured after 30 mins by fluorescence assay |
Bioorg Med Chem 25: 714-726 (2017)
Article DOI: 10.1016/j.bmc.2016.11.048 BindingDB Entry DOI: 10.7270/Q21C1ZVW |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate after 30 mins by fluorescence spectrophotometry |
Bioorg Med Chem 24: 2342-51 (2016)
Article DOI: 10.1016/j.bmc.2016.04.012 BindingDB Entry DOI: 10.7270/Q21N8316 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence assay |
Bioorg Med Chem 26: 1885-1895 (2018)
BindingDB Entry DOI: 10.7270/Q2J67KKZ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected High 5 insect cells using kynuramine as substrate incubated for 30 mins by sp... |
Bioorg Med Chem 25: 1030-1041 (2017)
Article DOI: 10.1016/j.bmc.2016.12.013 BindingDB Entry DOI: 10.7270/Q2PR7XZS |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorimetric ... |
Bioorg Med Chem 25: 1997-2009 (2017)
Article DOI: 10.1016/j.bmc.2017.02.027 BindingDB Entry DOI: 10.7270/Q2Q81GBJ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ... |
Bioorg Med Chem 26: 1102-1115 (2018)
BindingDB Entry DOI: 10.7270/Q2MW2KRT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate incubated for 30 mins by fluor... |
Eur J Med Chem 126: 762-775 (2017)
Article DOI: 10.1016/j.ejmech.2016.12.009 BindingDB Entry DOI: 10.7270/Q2NG4SW1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in rat liver mitochondria using serotonin as substrate preincubated with enzyme for 60 mins prior to substrate addition |
Bioorg Med Chem Lett 25: 70-4 (2015)
Article DOI: 10.1016/j.bmcl.2014.11.007 BindingDB Entry DOI: 10.7270/Q24F1SGH |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase A
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University
Curated by ChEMBL
| Assay Description Inhibition of bovine brain mitochondria MAO-A using serotonin substrate after 60 mins by fluorimetric method |
Bioorg Med Chem 23: 3574-85 (2015)
Article DOI: 10.1016/j.bmc.2015.04.021 BindingDB Entry DOI: 10.7270/Q28K7BVZ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Jena
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA |
J Med Chem 58: 6710-5 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00958 BindingDB Entry DOI: 10.7270/Q2QZ2CRZ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University
Curated by ChEMBL
| Assay Description Inhibition of bovine brain MAO-A preincubated for 60 mins before substrate addition by fluorimetric method |
Eur J Med Chem 93: 308-20 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.020 BindingDB Entry DOI: 10.7270/Q2VH5QJ9 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Alexandria University
Curated by ChEMBL
| Assay Description Inhibition of MAOA by spectrophotometry |
Eur J Med Chem 45: 4479-89 (2010)
Article DOI: 10.1016/j.ejmech.2010.07.008 BindingDB Entry DOI: 10.7270/Q21G0N86 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Assiut University
Curated by ChEMBL
| Assay Description Inhibition of bovine brain mitochondria MAO-A by spectrofluorimetry |
Eur J Med Chem 93: 481-91 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.039 BindingDB Entry DOI: 10.7270/Q2FX7C5D |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanyang Normal University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence method |
Bioorg Med Chem Lett 27: 5046-5052 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.057 BindingDB Entry DOI: 10.7270/Q2XS5XTR |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanyang Normal University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 30 mins by fluorescence ... |
Bioorg Med Chem 25: 3006-3017 (2017)
Article DOI: 10.1016/j.bmc.2017.03.070 BindingDB Entry DOI: 10.7270/Q2F76G04 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAO-A expressed in baculovirus-infected insect cells using p-tyramine as substrate preincubated for 15 min... |
Bioorg Med Chem 25: 633-645 (2017)
Article DOI: 10.1016/j.bmc.2016.11.032 BindingDB Entry DOI: 10.7270/Q2HH6N2G |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Xinxiang Medical University
Curated by ChEMBL
| Assay Description Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assay |
Eur J Med Chem 140: 392-402 (2017)
BindingDB Entry DOI: 10.7270/Q2HH6NK6 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(464/527 = 88%)† (Bos taurus) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Manipal College of Pharmaceutical Sciences
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in bovine brain mitochondria using serotonin as substrate preincubated for 30 mins measured after 30 mins by spectrofluorimetric ... |
Bioorg Med Chem Lett 25: 5281-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.048 BindingDB Entry DOI: 10.7270/Q2M90BH5 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Santiago de Compostela
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyra... |
Eur J Med Chem 46: 5838-51 (2011)
Article DOI: 10.1016/j.ejmech.2011.09.045 BindingDB Entry DOI: 10.7270/Q2VD6ZVK |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells by para-tyramine oxidation assay |
Bioorg Med Chem 18: 1273-9 (2010)
Article DOI: 10.1016/j.bmc.2009.12.029 BindingDB Entry DOI: 10.7270/Q2X63N2Z |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using p-tyramine substrate preincubated for 15 mins before substrate addition measured after 20 mins by fluores... |
Eur J Med Chem 62: 745-53 (2013)
Article DOI: 10.1016/j.ejmech.2013.01.039 BindingDB Entry DOI: 10.7270/Q2C82BN6 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using p-tyramine as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by fluor... |
Bioorg Med Chem 23: 3722-9 (2015)
Article DOI: 10.1016/j.bmc.2015.04.009 BindingDB Entry DOI: 10.7270/Q2S46TQR |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA assessed as H2O2 production by Amplex Red reagent-based assay |
J Med Chem 55: 8483-92 (2012)
Article DOI: 10.1021/jm300978h BindingDB Entry DOI: 10.7270/Q29Z962V |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Santiago de Compostela
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA by fluorimetric method |
J Med Chem 51: 6740-51 (2008)
Article DOI: 10.1021/jm800656v BindingDB Entry DOI: 10.7270/Q2NV9J3H |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Roma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA |
Eur J Med Chem 45: 800-4 (2010)
Article DOI: 10.1016/j.ejmech.2009.11.003 BindingDB Entry DOI: 10.7270/Q2CR5TH5 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human MAOA by fluorimetry |
Bioorg Med Chem 18: 5715-23 (2010)
Article DOI: 10.1016/j.bmc.2010.06.007 BindingDB Entry DOI: 10.7270/Q25D8S19 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento Farmaco Chimico Tecnologico
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected BTI insect cells assessed as hydrogen peroxide production after 15 mins by Amp... |
Eur J Med Chem 45: 4490-8 (2010)
Article DOI: 10.1016/j.ejmech.2010.07.009 BindingDB Entry DOI: 10.7270/Q2FT8M7J |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate incubated for 15 mins prior to substrate... |
Eur J Med Chem 58: 405-17 (2012)
Article DOI: 10.1016/j.ejmech.2012.10.032 BindingDB Entry DOI: 10.7270/Q20G3M75 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect sells assessed as hydrogen peroxide production by fluorim... |
J Med Chem 54: 2155-64 (2011)
Article DOI: 10.1021/jm1013709 BindingDB Entry DOI: 10.7270/Q2902435 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected insect BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-t... |
J Med Chem 53: 6516-20 (2010)
Article DOI: 10.1021/jm100120s BindingDB Entry DOI: 10.7270/Q26H4HNW |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus-infected BTI-TN-5B1-4 cell microsomes assessed as decrease in H2O2 production using p-... |
Bioorg Med Chem 22: 2887-95 (2014)
Article DOI: 10.1016/j.bmc.2014.03.042 BindingDB Entry DOI: 10.7270/Q2C53NCP |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BT1 cells |
Bioorg Med Chem Lett 20: 6479-82 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.061 BindingDB Entry DOI: 10.7270/Q2HM59QH |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Quaid-i-Azam University
| Assay Description The assay was performed in a polystyrene 96-well plate having flat bottom containing 200 μL of the total reaction mixture. For each assay, mixtu... |
Bioorg Chem 70: 17-26 (2017)
Article DOI: 10.1016/j.bioorg.2016.11.004 BindingDB Entry DOI: 10.7270/Q2WM1C7Z |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Sapienza University of Rome
| Assay Description The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide... |
J Med Chem 52: 2818-24 (2009)
Article DOI: 10.1021/jm801590u BindingDB Entry DOI: 10.7270/Q2X63K8T |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAOA expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decre... |
Eur J Med Chem 158: 781-800 (2018)
BindingDB Entry DOI: 10.7270/Q2F192DM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ La Sapienza
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAO-A expressed in baculovirus-infected insect BTI-TN-5B1-4 cells assessed as p-tyramine conversion to H2O... |
Bioorg Med Chem Lett 23: 5128-30 (2013)
BindingDB Entry DOI: 10.7270/Q2WD43H9 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
"G. D'Annunzio" University of Chieti-Pescara
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 20 mins by fluorescence assay |
Eur J Med Chem 143: 1543-1552 (2018)
BindingDB Entry DOI: 10.7270/Q27H1N3J |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Government College University
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30... |
Eur J Med Chem 143: 1373-1386 (2018)
BindingDB Entry DOI: 10.7270/Q21V5HHC |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAOA expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decre... |
J Med Chem 60: 7206-7212 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00918 BindingDB Entry DOI: 10.7270/Q23B62KQ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BT1-TN-5B1-4 cells assessed as inhibition of production of hydrogen peroxide ... |
Eur J Med Chem 59: 91-100 (2013)
Article DOI: 10.1016/j.ejmech.2012.11.006 BindingDB Entry DOI: 10.7270/Q2T43VFR |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Roma
Curated by ChEMBL
| Assay Description Inhibition of human recombinant microsomal MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate assessed as reduc... |
Eur J Med Chem 117: 292-300 (2016)
Article DOI: 10.1016/j.ejmech.2016.03.081 BindingDB Entry DOI: 10.7270/Q2JW8GSP |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI cells using p-tyramine as substrate after 15 mins by Amplex Red-based flu... |
Eur J Med Chem 108: 542-52 (2016)
Article DOI: 10.1016/j.ejmech.2015.12.026 BindingDB Entry DOI: 10.7270/Q2GX4DFK |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi Magna Gr£cia di Catanzaro
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as inhibition of hydrogen peroxide product... |
Eur J Med Chem 48: 284-95 (2012)
Article DOI: 10.1016/j.ejmech.2011.12.027 BindingDB Entry DOI: 10.7270/Q2JS9QW8 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratorio de Quimica Medica (IQOG, CSIC)
Curated by ChEMBL
| Assay Description Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 15 mins |
J Med Chem 57: 10455-63 (2014)
Article DOI: 10.1021/jm501501a BindingDB Entry DOI: 10.7270/Q2WS8VX3 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"Aldo Moro"
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using kynuramine substrate by spectrophotometric assay |
J Med Chem 58: 5561-78 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00599 BindingDB Entry DOI: 10.7270/Q26T0PCZ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyra... |
Bioorg Med Chem 18: 5063-70 (2010)
Article DOI: 10.1016/j.bmc.2010.05.070 BindingDB Entry DOI: 10.7270/Q22F7PD1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Magna Graecia di Catanzaro
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A assessed as inhibition of production of hydrogen peroxide after 15 mins by Amplex Red fluorimetric method |
Bioorg Med Chem Lett 20: 2709-12 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.081 BindingDB Entry DOI: 10.7270/Q22V2G80 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Anadolu University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using tyramine as substrate pretreated for 30 mins followed ... |
Eur J Med Chem 131: 92-106 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.009 BindingDB Entry DOI: 10.7270/Q2MG7RZB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunchon National University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate addition |
Bioorg Med Chem Lett 28: 584-588 (2018)
BindingDB Entry DOI: 10.7270/Q25T3P2R |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mississippi
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using kynuramine as substrate preincubated with compound for 15 mins measured after 20 mins by fluorometric ana... |
Bioorg Med Chem Lett 22: 4926-9 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.058 BindingDB Entry DOI: 10.7270/Q21Z45GF |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using kynuramine as substrate after 30 mins by fluorescence assay |
Bioorg Med Chem Lett 27: 718-722 (2017)
Article DOI: 10.1016/j.bmcl.2017.01.050 BindingDB Entry DOI: 10.7270/Q2JM2CX6 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Sichuan University
| Assay Description Recombinant human MAO-A and MAO-B (5 mg/mL) were purchased from Sigma-Aldrich, pre-aliquoted and stored at -80 °C. Solutions of test compounds we... |
Bioorg Chem 71: 305-314 (2017)
Article DOI: 10.1016/j.bioorg.2017.02.016 BindingDB Entry DOI: 10.7270/Q2X9295T |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAOA using p-tyramine as substrate after 30 mins by Amplex red based spectrophotometric analysis |
Bioorg Med Chem 23: 6486-96 (2015)
Article DOI: 10.1016/j.bmc.2015.08.012 BindingDB Entry DOI: 10.7270/Q2MK6FPP |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by... |
Bioorg Med Chem 26: 232-244 (2018)
BindingDB Entry DOI: 10.7270/Q2959M4S |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sunchon National University
Curated by ChEMBL
| Assay Description Reversible inhibition of recombinant human MAO-A assessed as residual activity using kynuramine as substrate preincubated for 30 mins followed by dia... |
Bioorg Med Chem Lett 28: 2403-2407 (2018)
BindingDB Entry DOI: 10.7270/Q23R0WCT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Parma
Curated by ChEMBL
| Assay Description Inhibition of human MAOA after 1 hr by luminescence assay |
J Med Chem 56: 1247-61 (2013)
Article DOI: 10.1021/jm301686s BindingDB Entry DOI: 10.7270/Q2SB472H |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAOA using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by ... |
Eur J Med Chem 143: 33-47 (2018)
BindingDB Entry DOI: 10.7270/Q2C53PC3 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA using p-tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by horse... |
Eur J Med Chem 121: 864-879 (2016)
Article DOI: 10.1016/j.ejmech.2015.10.001 BindingDB Entry DOI: 10.7270/Q2B27X8T |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB US Patent
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm S.p.A
US Patent
| Assay Description Inhibitory activity of compounds was evaluated by a homogeneous luminescent method, the MAO-Glo Assay (Promega), measuring the monoamine oxidase acti... |
US Patent US8633208 (2014)
BindingDB Entry DOI: 10.7270/Q23J3BMD |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Okayama University
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in rat liver homogenate using [14C]-5HT as substrate preincubated for 30 mins followed by substrate addition measured after 20 mi... |
Eur J Med Chem 80: 543-61 (2014)
Article DOI: 10.1016/j.ejmech.2014.04.078 BindingDB Entry DOI: 10.7270/Q2BK1DWK |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 30.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Karolinska Institutet
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in insect cells assessed as inhibition of kynuramine oxidation after 30 mins by fluorescence assay |
J Med Chem 54: 7023-9 (2011)
Article DOI: 10.1021/jm200710b BindingDB Entry DOI: 10.7270/Q2765FQJ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAO-A using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured over 15 mins by ... |
Eur J Med Chem 145: 588-593 (2018)
BindingDB Entry DOI: 10.7270/Q2JD50CJ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 189 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human microsomal MAO-A expressed in baculovirus-infected insect cells using p-tyramine as substrate assessed as H2O2 produc... |
Bioorg Med Chem 24: 1741-8 (2016)
Article DOI: 10.1016/j.bmc.2016.02.045 BindingDB Entry DOI: 10.7270/Q2T72K99 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro Inhibitory activity of Monoamine oxidase at rat hyphalamic mitochondrial PEA by displacing 2.5 uM of [14C]PEA (phenethylamine) |
J Med Chem 26: 1036-42 (1983)
Article DOI: 10.1021/jm00361a017 BindingDB Entry DOI: 10.7270/Q2K076FV |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of MAOA in rat liver homogenates preincubated for 60 mins |
Bioorg Med Chem Lett 18: 6362-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.084 BindingDB Entry DOI: 10.7270/Q2GT5N1F |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 2.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hacettepe University
Curated by ChEMBL
| Assay Description Inhibition of MAO-A in rat liver homogenate after 60 mins by residual activity plot |
Bioorg Med Chem 17: 675-89 (2009)
Article DOI: 10.1016/j.bmc.2008.11.068 BindingDB Entry DOI: 10.7270/Q2BG2NWT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB MMDB
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| n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hacettepe University
Curated by ChEMBL
| Assay Description Inhibition of rat liver MAOA after 60 mins pre-incubation |
Bioorg Med Chem 15: 5775-86 (2007)
Article DOI: 10.1016/j.bmc.2007.06.004 BindingDB Entry DOI: 10.7270/Q2JH3N0R |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MAOA using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate additio... |
Eur J Med Chem 103: 185-90 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.055 BindingDB Entry DOI: 10.7270/Q29C7070 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 2.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A using p-tyramine as substrate assessed as production of H2O2 incubated for 15 mins prior to substrate addition ... |
Bioorg Med Chem 23: 515-25 (2015)
Article DOI: 10.1016/j.bmc.2014.12.010 BindingDB Entry DOI: 10.7270/Q2R2132N |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 4.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAOA |
J Med Chem 51: 4874-80 (2008)
Article DOI: 10.1021/jm800132g BindingDB Entry DOI: 10.7270/Q27P8Z5J |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Amine oxidase (flavin-containing) A
(527/527 = 100%)† (Homo sapiens (Human)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | 4.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza University of Rome
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramin... |
Eur J Med Chem 46: 4846-52 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.017 BindingDB Entry DOI: 10.7270/Q2QV3MXF |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Monoamine oxidase
(459/525 = 87%)† (Rattus norvegicus (rat)) | BDBM15581
 (CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3 | PDB
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| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against rat brain mitochondrial Monoamine oxidase |
J Med Chem 28: 186-93 (1985)
Article DOI: 10.1021/jm00380a007 BindingDB Entry DOI: 10.7270/Q26M3910 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |