Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CDK2/Cyclin A/Cyclin A1 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM12028![]() (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of CDK2/Cyclin A (174 to 432 amino acid residues) (unknown origin) by differential scanning fluorimetry assay | J Med Chem 56: 660-70 (2013) Article DOI: 10.1021/jm301495v BindingDB Entry DOI: 10.7270/Q28G8N18 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
CDK2/CycE (298/298 = 100%)† (Homo sapiens (Human)) | BDBM12028![]() (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Palacky University | Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P... | J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase 2 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM12028![]() (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Experimental Botany ASCR and Palacky University | Assay Description Cyclin-dependent kinase selectivity was evaluated using CDK1-cyclin B, CDK2-cyclin E, CDK4-cyclin D1, CDK7-cyclin H, and CDK9-cyclin T1. | Chem Biol Drug Des 84: 402-8 (2014) Article DOI: 10.1111/cbdd.12330 BindingDB Entry DOI: 10.7270/Q28C9TXB | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cyclin-Dependent Kinase 2 (CDK2) (298/298 = 100%)† (Homo sapiens (Human)) | BDBM12028![]() (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | 30 |
Palacky University | Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P... | J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |