Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
beta-Secretase (BACE-1) (400/400 = 100%)† (Homo sapiens (Human)) | BDBM16088![]() ((2R,4S)-4-[(4aS,12R,15S,17aS)-15-methyl-14,17-diox...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | 25 |
Universite de Montreal at Succursale Centre-Ville | Assay Description Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ... | J Med Chem 49: 4544-67 (2006) Article DOI: 10.1021/jm060154a BindingDB Entry DOI: 10.7270/Q2RV0KZN | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |