Affinity Data by PDB ID

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PDB code 2FPV

Identical Ligands in BindingDB

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydroorotate Dehydrogenase (DHODH) (367/367 = 100%)^† (Homo sapiens (Human))	BDBM16114 (3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	8.0	25
4SC AG					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				Bioorg Med Chem Lett 16: 267-70 (2006) Article DOI: 10.1016/j.bmcl.2005.10.011 BindingDB Entry DOI: 10.7270/Q2CJ8BQ4
4SC AG					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (367/367 = 100%)^† (Homo sapiens (Human))	BDBM16114 (3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	8.0	30
4SC AG					Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...				J Med Chem 49: 1239-47 (2006) Article DOI: 10.1021/jm0506975 BindingDB Entry DOI: 10.7270/Q2571988
4SC AG					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output