Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-Dependent Protein Kinase (PKA) (337/350 = 96%)† (Mus musculus (mouse)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 460 | -36.8 | n/a | n/a | n/a | n/a | n/a | 7.6 | 30 |
Vertex Pharmaceuticals Inc | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 260-8 (2006) Article DOI: 10.1074/jbc.M508847200 BindingDB Entry DOI: 10.7270/Q2JQ0Z80 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
PKA (318/350 = 91%)† (RAT) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Temple University Curated by PDSP Ki Database | J Pharmacol Exp Ther 316: 869-74 (2006) Article DOI: 10.1124/jpet.105.097303 BindingDB Entry DOI: 10.7270/Q2PN9464 | ||||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (Q181K/T183A) (347/350 > 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 541 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (T183A) (346/350 = 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 607 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-dependent protein kinase (PKA) (343/350 = 98%)† (Homo sapiens (Human)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PCBioAssay | n/a | n/a | 853 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ... | PubChem Bioassay (2007) Article DOI: 10.1186/2191-2858-2-21 BindingDB Entry DOI: 10.7270/Q24X565S | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (L49I/Q181K/T183A) (348/350 > 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (L49I) (346/350 = 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 893 | n/a | n/a | n/a | n/a | 6.8 | 25 |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (L49I/V123M/Q181K/T183A) (349/350 > 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (V123M/T183A) (347/350 > 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) (345/350 = 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.49E+3 | n/a | n/a | n/a | n/a | 6.8 | 25 |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (V123M/Q181K/T183A) (348/350 > 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (L49I/V123M/E127D/Q181K/T183A) (350/350 = 100%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (E127D) (346/350 = 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-Dependent Protein Kinase (PKA) Mutant (V123M) (346/350 = 99%)† (Bos taurus (bovine)) | BDBM14027![]() (5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 7.61E+3 | n/a | n/a | n/a | n/a | 6.8 | 25 |
German Cancer Research Center | Assay Description The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin... | J Biol Chem 281: 24818-30 (2006) Article DOI: 10.1074/jbc.M512374200 BindingDB Entry DOI: 10.7270/Q2PG1PZV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |