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Found 8 Enz. Inhib. hit(s) for PDB: 2ITT
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Norwegian University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR by Z-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1022,G719S](Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  11.3nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1022,L858R](Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  1.70nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1022,T790M](Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  27.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1022,L858R](Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  1.10nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1022,T790M,L858R](Homo sapiens (Human))
Harvard Medical School

LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  18.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Norwegian University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  10.9nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Norwegian University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM26105(6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...)
Affinity DataKd:  5.30nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair