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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Angiopoietin-1 receptor (317/317 = 100%)† (Homo sapiens (Human)) | BDBM14974 (CHEMBL221484 | N-(3-(3-(Dimethylamino)propyl)-5-(t...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of Tie2 after 90 mins by HTRF assay | Bioorg Med Chem Lett 17: 2886-9 (2007) Article DOI: 10.1016/j.bmcl.2007.02.067 BindingDB Entry DOI: 10.7270/Q2445M4C | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Angiopoietin-1 receptor (317/317 = 100%)† (Homo sapiens (Human)) | BDBM14974 (CHEMBL221484 | N-(3-(3-(Dimethylamino)propyl)-5-(t...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | J Med Chem 50: 611-26 (2007) Article DOI: 10.1021/jm061107l BindingDB Entry DOI: 10.7270/Q2MC8X8S | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
