Found 19 Enz. Inhib. hit(s) for PDB: 2P16 
Affinity DataKi: 0.0750nM ΔG°: -57.8kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.0800nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Binding affinity to human coagulation factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Inhibition of purified human factor XaMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nM ΔG°: -57.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nM ΔG°: -57.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nM ΔG°: -56.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of peptide substrate cleavage by FXa was assayed against six concentrations of S2765 and six concentrations of apixaban. Typical assays we...More data for this Ligand-Target Pair
Affinity DataKi: 0.410nM ΔG°: -53.6kJ/molepH: 7.5 T: 2°CAssay Description:For comparison with the prothrombinase reaction the assays were also conducted with S2765 at 25 and 37°C in a similar buffer: 20 mM HEPES, pH 7.5 con...More data for this Ligand-Target Pair
Affinity DataKi: 0.720nM ΔG°: -54.3kJ/molepH: 7.5 T: 2°CAssay Description:For comparison with the prothrombinase reaction the assays were also conducted with S2765 at 25 and 37°C in a similar buffer: 20 mM HEPES, pH 7.5 con...More data for this Ligand-Target Pair
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical
US Patent
North China Pharmaceutical
US Patent
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of human F10a assessed as decrease in p-nitroaniline cleavage from pefachrome F10a preincubated for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of human coagulation factor 10a assessed as reduction in p-nitroaniline cleavage from pefachrome substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
