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Report error Found 14 Enz. Inhib. hit(s) for PDB: 2PFH
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16313(2-(2-{[(4-bromo-2-fluorophenyl)methyl]carbamothioy...)
Affinity DataIC50:  3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human ALR2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  9nMAssay Description:Tested for in vitro inhibition activity against human Aldose reductase (human AR)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rat)
Beijing Institute of Technology

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  29nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2 by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16313(2-(2-{[(4-bromo-2-fluorophenyl)methyl]carbamothioy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of AR (unknown origin)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16313(2-(2-{[(4-bromo-2-fluorophenyl)methyl]carbamothioy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli by Coomassie reagent assayMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16313(2-(2-{[(4-bromo-2-fluorophenyl)methyl]carbamothioy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  30nMAssay Description:Binding affinity for human Aldose reductase 2 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  35nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rat)
Beijing Institute of Technology

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  35nMAssay Description:Tested for in vitro inhibition activity against rat Aldose reductase (AR)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rat)
Beijing Institute of Technology

Curated by ChEMBL
LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataIC50:  35nMAssay Description:Inhibitory concentration against rat ALR2 aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Human)
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire

LigandPNGBDBM16512((2S,4S)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[1-be...)
Affinity DataKd:  16nMpH: 8.5Assay Description:The anti-His antibody (His Capture Kit, GE Healthcare) was immobilized on sensor chip CM5 (GE Healthcare), in a Biacore T200 or Biacore S200 instrume...More data for this Ligand-Target Pair