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Found 4 Enz. Inhib. hit(s) for PDB: 2Q15
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  8nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM17786((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant beta-secretase 1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Evotec

Curated by ChEMBL
LigandPNGBDBM17785(2-aminoquinazoline, 3 | 4-(2-amino-6-phenoxy-3,4-d...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 5.0 T: 2°CAssay Description:BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...More data for this Ligand-Target Pair