Affinity Data by PDB ID

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PDB code 2UV6

Identical Ligands in BindingDB

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5'-AMP-activated protein kinase Complex 1 (143/144 > 99%)^† (Homo sapiens (Human))	BDBM18137 (AMP \| CHEMBL752 \| [(2R,3S,4R,5R)-5-adenin-9-yl-3,4...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assay				J Med Chem 59: 8068-81 (2016) Article DOI: 10.1021/acs.jmedchem.6b00866 BindingDB Entry DOI: 10.7270/Q2PZ5BRC
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
5'-AMP-activated protein kinase Complex 1 (143/144 > 99%)^† (Homo sapiens (Human))	BDBM18137 (AMP \| CHEMBL752 \| [(2R,3S,4R,5R)-5-adenin-9-yl-3,4...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...				J Med Chem 59: 8068-81 (2016) Article DOI: 10.1021/acs.jmedchem.6b00866 BindingDB Entry DOI: 10.7270/Q2PZ5BRC
Pfizer Inc Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output