Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.5nMT: 25°CAssay Description:The activity of renin inhibitors in vitro was measured using the FRET assay, which was carried out in flat-bottom white opaque microtiter plates. The...More data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of purified recombinant human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Enzyme inhibition by test compounds was determined using human recombinant renin, incubating with a synthetic tetradecapeptide substrate. The Ang I g...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMpH: 7.2 T: 37°CAssay Description:In vitro potencies of compounds against purified human recombinant renin were determined by its cleavage of substrate angiotensinogen. The angiotensi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin activity in human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant rennin in buffer assessed as accumulation of angiotensin 1 using human tetradecapeptide by immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human reninMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin in plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant glycosylated human renin expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant renin using Nma-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-Dnp substrate incubated for 1 hr by FRETMore data for this Ligand-Target Pair
Affinity DataIC50: 0.840nMAssay Description:Inhibition of renin in human plasma by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of renin in monkey plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant renin compound treated for 10 mins before substrate addition measured after 90 mins by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.21nMAssay Description:Inhibition of renin measured every 30 secs for 15 mins by fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant renin preincubated for 30 mins followed by substrate addition measured after 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of renin activity in human plasma by competitive radio immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human renin using 5-FAM/QXL 520 as substrate pretreated for 30 mins followed by substrate addition measured at 1 min interv...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of cynomolgus monkey plasma renin activity after 60 mins by competitive RIAMore data for this Ligand-Target Pair
