Found 3 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-Dependent Kinase 2 (CDK2)
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM24627
 (1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar
| Purchase
CHEBI MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 1.85E+5 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex
| Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... |
J Med Chem 51: 4986-99 (2008)
Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Cyclin-dependent kinase 2
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM24627
 (1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| Purchase
CHEBI MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 1.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
J Med Chem 54: 5131-43 (2011)
Article DOI: 10.1021/jm200349b BindingDB Entry DOI: 10.7270/Q2F47PHP |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
CDK2/Cyclin A/Cyclin A1
(298/298 = 100%)† (Homo sapiens (Human)) | BDBM24627
 (1H-indazole | Indazole, 5 | Indazole, 6)Show InChI InChI=1S/C7H6N2/c1-2-4-7-6(3-1)5-8-9-7/h1-5H,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar
| Purchase
CHEBI MMDB PC cid PC sid PDB UniChem
Patents
| PDB Article PubMed
| n/a | n/a | 1.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assay |
Bioorg Med Chem Lett 25: 3420-35 (2015)
Article DOI: 10.1016/j.bmcl.2015.05.100 BindingDB Entry DOI: 10.7270/Q2736SQ1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |