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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cyclin-Dependent Kinase 2 (CDK2) (298/298 = 100%)† (Homo sapiens (Human)) | BDBM50368897 (CHEMBL463580) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar | PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of C-terminal His6-tagged human full length CDK2/N-terminal GST-tagged human full length Cyclin A using histone H1 and [gamma-32P]-ATP inc... | J Med Chem 61: 7700-7709 (2018) BindingDB Entry DOI: 10.7270/Q2GX4F3H | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Cyclin-Dependent Kinase 2 (CDK2) (298/298 = 100%)† (Homo sapiens (Human)) | BDBM24643 (4-N-benzene-3-N-(4-fluorophenyl)-1H-pyrazole-3,4-d...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Astex | Assay Description CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1.... | J Med Chem 51: 4986-99 (2008) Article DOI: 10.1021/jm800382h BindingDB Entry DOI: 10.7270/Q24X563W | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
