Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat Shock Protein 90 (Hsp90) (218/220 > 99%)† (Saccharomyces cerevisiae) | BDBM15361![]() ((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham | Assay Description Binding competition assay with a fluorescent probe. | Chem Biol 13: 1203-15 (2006) Article DOI: 10.1016/j.chembiol.2006.09.015 BindingDB Entry DOI: 10.7270/Q2930RMM | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Heat Shock Protein 90 (Hsp90) (218/220 > 99%)† (Saccharomyces cerevisiae) | BDBM15361![]() ((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham | Assay Description Binding competition assay with a fluorescent probe. | Chem Biol 13: 1203-15 (2006) Article DOI: 10.1016/j.chembiol.2006.09.015 BindingDB Entry DOI: 10.7270/Q2930RMM | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Heat Shock Protein 90 (Hsp90) (218/220 > 99%)† (Saccharomyces cerevisiae) | BDBM15361![]() ((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | <200 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Vernalis (R&D) Ltd | Assay Description The HSP90 ATPase activity was determined by following the procedure of malachite green assay. The assay is based on quantitation of the green complex... | Chem Biol 11: 775-85 (2004) Article DOI: 10.1016/j.chembiol.2004.03.033 BindingDB Entry DOI: 10.7270/Q2RX99BC | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Heat Shock Protein 90 (Hsp90) (218/220 > 99%)† (Saccharomyces cerevisiae) | BDBM15361![]() ((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham | Assay Description A colorimetric assay for the release of inorganic phosphate upon hydrolysis of ATP was used to determine the potency of Hsp 90 inhibitor against enzy... | Chem Biol 13: 1203-15 (2006) Article DOI: 10.1016/j.chembiol.2006.09.015 BindingDB Entry DOI: 10.7270/Q2930RMM | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |