Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate Reductase (DHFR) (217/217 = 100%)† (Candida Glabrata) | BDBM26519![]() (5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylp...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar | DrugBank MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | 25 |
University of Connecticut | Assay Description Enzyme inhibition assay using CgDHFR and hDHFR performed at 25 degree Celsius by monitoring the rate of enzyme-dependent NADPH oxidation at an absorb... | Chem Biol 15: 990-6 (2008) Article DOI: 10.1016/j.chembiol.2008.07.013 BindingDB Entry DOI: 10.7270/Q290228K | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |