Affinity Data by PDB ID

PDB code 3CSE

Found 1 hit Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate Reductase (DHFR) (217/217 = 100%)^† (Candida Glabrata)	BDBM26519 (5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylp...) Show SMILES CCc1nc(N)nc(N)c1C#CCc1cc(OC)ccc1OC Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	25
University of Connecticut					Assay Description Enzyme inhibition assay using CgDHFR and hDHFR performed at 25 degree Celsius by monitoring the rate of enzyme-dependent NADPH oxidation at an absorb...				Chem Biol 15: 990-6 (2008) Article DOI: 10.1016/j.chembiol.2008.07.013 BindingDB Entry DOI: 10.7270/Q290228K
University of Connecticut					More data for this Ligand-Target Pair				3D Structure (crystal)

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output