Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glycogen Phosphorylase (PYGL) (846/846 = 100%)† (Homo sapiens (Human)) | BDBM27726![]() ((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.6 | 25 |
GSK | Assay Description An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t... | Bioorg Med Chem Lett 19: 1177-82 (2009) Article DOI: 10.1016/j.bmcl.2008.12.085 BindingDB Entry DOI: 10.7270/Q22805ZM | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Glycogen Phosphorylase (PYGL) (846/846 = 100%)† (Homo sapiens (Human)) | BDBM27726![]() ((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assay | Bioorg Med Chem Lett 19: 981-5 (2009) Article DOI: 10.1016/j.bmcl.2008.11.084 BindingDB Entry DOI: 10.7270/Q2319VRH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Glycogen Phosphorylase (PYGL) (846/846 = 100%)† (Homo sapiens (Human)) | BDBM27726![]() ((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of liver glycogen phosphorylase A in human HepG2 cells assessed as inhibition of forskolin-induced glucogenolysis | Bioorg Med Chem Lett 19: 981-5 (2009) Article DOI: 10.1016/j.bmcl.2008.11.084 BindingDB Entry DOI: 10.7270/Q2319VRH | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Liver glycogen phosphorylase (802/847 = 95%)† (Rattus norvegicus) | BDBM10849![]() (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 6.48E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibitory concentration against rat liver glycogen phosphorylase | Bioorg Med Chem Lett 15: 4944-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.026 BindingDB Entry DOI: 10.7270/Q27M08R5 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |