Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 8 Enz. Inhib. hit(s) for PDB: 3E7T
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  35nMpH: 7.0 T: 37°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibition of human Inducible nitric oxide synthase.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  37nMAssay Description:Inhibitory activity of compound against human inducible nitiric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  37.1nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant iNOSMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human iNOS expressed in human DLD1 cells after 1 hrMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  210nMAssay Description:Inhibition of cytokine-induced iNOS activity in human DLD1 cells after 24 hrsMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Human)
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide productionMore data for this Ligand-Target Pair