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Report error Found 7 Enz. Inhib. hit(s) for PDB: 3E9S
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  230nMpH: 7.5Assay Description:done in a single pass in black 384-well plates (Matrix Technologies). The SARS-PLpro enzyme (20 nM final concentration) was prepared in an assay buff...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM31523(Compound 6 | Naphthalene and Benzamide Derivative,...)
Affinity DataIC50:  560nMpH: 7.5 T: 23°CAssay Description:IC50 values for all inhibitors were determined using a 96-well plate based assay. Reactions were performed in buffer containing RLRGG-AMC, 2% DMSO, a...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM31523(Compound 6 | Naphthalene and Benzamide Derivative,...)
Affinity DataIC50:  560nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a(SARS-CoV)
University of Bonn

LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  600nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
Arizona Board of Regents on Behalf of the University of Arizona; The Board of Trustees of the University of Illinois

US Patent
LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  1.61E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab [1541-1855](Human SARS coronavirus (SARS-CoV))
University of Illinois At Chicago

LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataIC50:  2.64E+3nMpH: 7.5 T: 23°CAssay Description:IC50 values for all inhibitors were determined using a 96-well plate based assay. Reactions were performed in buffer containing RLRGG-AMC, 2% DMSO, a...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
Arizona Board of Regents on Behalf of the University of Arizona; The Board of Trustees of the University of Illinois

US Patent
LigandPNGBDBM31524(5-amino-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]...)
Affinity DataKd:  2.70E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair