Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate Reductase (DHFR) (217/217 = 100%)† (Candida Glabrata) | BDBM25818![]() (5-[3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]-6-me...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut | Assay Description Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min. | Chem Biol Drug Des 73: 62-74 (2009) Article DOI: 10.1111/j.1747-0285.2008.00745.x BindingDB Entry DOI: 10.7270/Q29K48RZ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |