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Found 7 Enz. Inhib. hit(s) for PDB: 3G3E
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  4nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human recombinant DAAO after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  42nMAssay Description:Inhibition of DAAO (unknown origin) by cell based assayMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Sus scrofa (pig))
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataIC50:  100nMAssay Description:Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Sus scrofa (pig))
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataKd:  150nMAssay Description:Binding affinity to pig kidney DAAO by ITC methodMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31148(3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)
Affinity DataKd:  13nMAssay Description:Binding affinity and kinetics were measured using biotinylated recombinant human DAAO bound to a Neutravidin surface in a Biacore binding assay. A cu...More data for this Ligand-Target Pair