Found 7 hits Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM31148
 (3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 8.5 | 22 |
Pfizer Inc
| Assay Description Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox... |
J Med Chem 52: 3576-85 (2009)
Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM31148
 (3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DAAO after 30 mins by plate reader analysis |
J Med Chem 56: 3582-92 (2013)
Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM31148
 (3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc
Curated by ChEMBL
| Assay Description Inhibition of DAAO (unknown origin) by cell based assay |
J Med Chem 56: 3582-92 (2013)
Article DOI: 10.1021/jm400095b BindingDB Entry DOI: 10.7270/Q2HT2QPZ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM31148
 (3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiao Tong University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysis |
Eur J Med Chem 117: 19-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.04.017 BindingDB Entry DOI: 10.7270/Q2V989ZS |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
D-Amino Acid Oxidase (DAAO)
(294/347 = 85%)† (Sus scrofa (pig)) | BDBM31148
 (3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiao Tong University
Curated by ChEMBL
| Assay Description Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade... |
Eur J Med Chem 117: 19-32 (2016)
Article DOI: 10.1016/j.ejmech.2016.04.017 BindingDB Entry DOI: 10.7270/Q2V989ZS |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
D-Amino Acid Oxidase (DAAO)
(294/347 = 85%)† (Sus scrofa (pig)) | BDBM31148
 (3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a |
Hungarian Academy of Sciences
Curated by ChEMBL
| Assay Description Binding affinity to pig kidney DAAO by ITC method |
Bioorg Med Chem 26: 1579-1587 (2018)
BindingDB Entry DOI: 10.7270/Q2VQ359V |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
D-amino-acid oxidase
(347/347 = 100%)† (Homo sapiens (Human)) | BDBM31148
 (3-hydroxyquinolin-2(1H)-one, 2 | US9701638, 1)Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar
| Purchase
MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
| Assay Description Binding affinity and kinetics were measured using biotinylated recombinant human DAAO bound to a Neutravidin surface in a Biacore binding assay. A cu... |
J Med Chem 52: 3576-85 (2009)
Article DOI: 10.1021/jm900128w BindingDB Entry DOI: 10.7270/Q2CZ35HM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |