Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Ionotropic glutamate receptor kainate 2/5 (141/144 = 98%)† (Rattus norvegicus) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Curated by ChEMBL | Assay Description Displacement of [3H]SYM2081 from rat iGluR6 receptor expressed in Sf9 cells baculovirus system after 1 to 2 hrs by liquid scintillation counting | J Med Chem 53: 4110-8 (2010) Article DOI: 10.1021/jm1001452 BindingDB Entry DOI: 10.7270/Q2RR206G | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Ionotropic glutamate receptor kainate 2/5 (141/144 = 98%)† (Rattus norvegicus) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 331 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK2(VCR) receptor expressed in sf9 cells by liquid scintillati... | J Med Chem 56: 1614-28 (2013) Article DOI: 10.1021/jm301433m BindingDB Entry DOI: 10.7270/Q23F4R0N | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Ionotropic glutamate receptor kainate 2/5 (141/144 = 98%)† (Rattus norvegicus) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 331 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Blaise Pascal Curated by ChEMBL | Assay Description Displacement of [3H]SYM2081 from rat recombinant iGluR6 | J Med Chem 51: 4093-103 (2008) Article DOI: 10.1021/jm800092x BindingDB Entry DOI: 10.7270/Q20V8DP6 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Ionotropic glutamate receptor kainate 2/5 (141/144 = 98%)† (Rattus norvegicus) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 332 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
European Research Centre for Drug Discovery and Development (NatSynDrugs) Curated by ChEMBL | Assay Description Displacement of [3H]kainic acid from rat recombinant iGluR6(V,C,R) receptor expressed in Sf9 cells | J Med Chem 51: 6614-8 (2008) Article DOI: 10.1021/jm800865a BindingDB Entry DOI: 10.7270/Q261117R | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Glutamate receptor ionotropic, kainate 2 (141/144 = 98%)† (Homo sapiens (Human)) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd Curated by ChEMBL | Assay Description Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell... | Bioorg Med Chem Lett 10: 1807-10 (2000) Article DOI: 10.1016/s0960-894x(00)00346-2 BindingDB Entry DOI: 10.7270/Q2765FVB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ionotropic glutamate receptor kainate 2/5 (141/144 = 98%)† (Rattus norvegicus) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat recombinant GluR6(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo... | J Med Chem 52: 4911-22 (2009) Checked by Author Article DOI: 10.1021/jm900565c BindingDB Entry DOI: 10.7270/Q2R49RP9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Ionotropic glutamate receptor kainate 2/5 (141/144 = 98%)† (Rattus norvegicus) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.60E+4 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay | J Med Chem 51: 2311-5 (2008) Article DOI: 10.1021/jm701394a BindingDB Entry DOI: 10.7270/Q2Z320HT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (docked) | ||||||||||||
Glutamate receptor ionotropic, kainate 2 (141/144 = 98%)† (Homo sapiens (Human)) | BDBM17657![]() ((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEBI DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a |
Eli Lilly and Company Ltd Curated by ChEMBL | Assay Description Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells | Bioorg Med Chem Lett 10: 1807-10 (2000) Article DOI: 10.1016/s0960-894x(00)00346-2 BindingDB Entry DOI: 10.7270/Q2765FVB | |||||||||||
More data for this Ligand-Target Pair |