Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (349/352 > 99%)† (Homo sapiens (Human)) | BDBM50415001![]() (CHEMBL570015 | GSK-256066 | GSK-256066 (3)) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.00794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE4B by scintillation proximity assay | Bioorg Med Chem Lett 19: 5261-5 (2009) Article DOI: 10.1016/j.bmcl.2009.04.012 BindingDB Entry DOI: 10.7270/Q2K075HB | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (349/352 > 99%)† (Homo sapiens (Human)) | BDBM50415001![]() (CHEMBL570015 | GSK-256066 | GSK-256066 (3)) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | >0.0100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysis | J Med Chem 57: 4661-76 (2014) Article DOI: 10.1021/jm5001216 BindingDB Entry DOI: 10.7270/Q2708302 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (290/334 = 87%)† (Homo sapiens (Human)) | BDBM50415001![]() (CHEMBL570015 | GSK-256066 | GSK-256066 (3)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University | Assay Description This assay was performed at Takeda Pharmaceuticals using methods previously reported. | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |