Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 26 Enz. Inhib. hit(s) for PDB: 3HP5
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  0.800nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant p38alpha by liquid scintillation countingMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at p38 MAPK alpha (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  22nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity determined against human mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human p38-alpha kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  34nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  45nMAssay Description:Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  51nMAssay Description:Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  70nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  70nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  120nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  150nMAssay Description:Inhibition of LPS-induced p38-related Tumor necrosis factor alpha release by THP-1 cellsMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  150nMAssay Description:Inhibition of p38alpha in human whole blood assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  180nMAssay Description:Inhibition of p38alpha in human whole blood assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  700nMAssay Description:Inhibition of LPS-induced p38-related Tumor necrosis factor alpha release in human whole bloodMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human p38-alpha kinase phosphorylationMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKd:  2.80nMAssay Description:Binding constant for p38-alpha kinase domainMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKd:  2.80nMAssay Description:Binding constant for full-length p38-alphaMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKd:  3.20nMAssay Description:Average Binding Constant for p38-alpha; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TGFBR1 kinase domainMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TGFBR1 kinase domainMore data for this Ligand-Target Pair
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to p38alpha (unknown origin)More data for this Ligand-Target Pair