Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase 9A (325/325 = 100%)† (Homo sapiens (Human)) | BDBM50300099![]() (6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE9A expressed in Sf9 cells using [3H]cGMP as substrate after 30 mins by scintillation proximity assay | J Med Chem 55: 9045-54 (2012) Article DOI: 10.1021/jm3007799 BindingDB Entry DOI: 10.7270/Q24J0G79 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Phosphodiesterase 9A (325/325 = 100%)† (Homo sapiens (Human)) | BDBM50300099![]() (6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA | J Med Chem 52: 7946-9 (2009) Article DOI: 10.1021/jm9015334 BindingDB Entry DOI: 10.7270/Q2RV0NRS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Phosphodiesterase 9A (325/325 = 100%)† (Homo sapiens (Human)) | BDBM50300099![]() (6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE9A expressed in Sf9 cells by SPA | J Med Chem 52: 7946-9 (2009) Article DOI: 10.1021/jm9015334 BindingDB Entry DOI: 10.7270/Q2RV0NRS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |