Affinity Data by PDB ID

Search and Browse
- Target
- Compound
- Special tools
- Citation
- Special Data Sets
- Other Databases
  - PDB 85% 100% Seq ID
  - UniProtKB/Swiss-Prot
  - UniProtKB/TrEMBL
  - PubMed
Download
- All Compounds & Data
- Target Names &
  - Ki IC50 Kd EC50
  - ΔG° ΔH° -TΔS°
Enter Data

PDB code 3MDY

Identical Ligands in BindingDB

Found 4 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bone morphogenetic protein receptor type-1B (BMPR1B) (335/335 = 100%)^† (Homo sapiens (Human))	BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Inhibition of human ALK6 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay				J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4
Korea University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Activin receptor-like kinase 3 (ALK-3) (285/335 = 85%)^† (Homo sapiens (Human))	BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Korea University Curated by ChEMBL					Assay Description Inhibition of human ALK3 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay				J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4
Korea University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
ALK3 (286/334 = 86%)^† (Mus musculus)	BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts Institute of Technology									ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW
Massachusetts Institute of Technology					More data for this Ligand-Target Pair				3D Structure (crystal)
Bone morphogenetic protein receptor type-1B (BMPR1B) (335/335 = 100%)^† (Homo sapiens (Human))	BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of ALK6 (unknown origin)				Bioorg Med Chem Lett 23: 3248-52 (2013) Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

Reorder this table by ec50
Reorder this table by ic50
Reorder this table by Kd
Reorder this table by pH
Reorder this table by T
Reorder this table by ΔH°
Reorder this table by -TΔS°
Change energy units to: kcal/mole

Search BindingMOAD for More Affinity Data:

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output