Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bone morphogenetic protein receptor type-1B (BMPR1B) (335/335 = 100%)† (Homo sapiens (Human)) | BDBM50262079![]() (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human ALK6 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Activin receptor-like kinase 3 (ALK-3) (285/335 = 85%)† (Homo sapiens (Human)) | BDBM50262079![]() (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of human ALK3 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay | J Med Chem 60: 1495-1508 (2017) Article DOI: 10.1021/acs.jmedchem.6b01679 BindingDB Entry DOI: 10.7270/Q2TQ63S4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK3 (286/334 = 86%)† (Mus musculus) | BDBM50262079![]() (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Activin receptor-like kinase 3 (ALK-3) (285/335 = 85%)† (Homo sapiens (Human)) | BDBM50262079![]() (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences Curated by ChEMBL | Assay Description Inhibition of ALK3 (unknown origin) using Ulight topo IIa (Thr 1342) peptide as substrate preincubated for 10 mins followed by substrate addition and... | Bioorg Med Chem Lett 28: 3356-3362 (2018) BindingDB Entry DOI: 10.7270/Q2NZ8BBT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bone morphogenetic protein receptor type-1B (BMPR1B) (335/335 = 100%)† (Homo sapiens (Human)) | BDBM50262079![]() (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of ALK6 (unknown origin) | Bioorg Med Chem Lett 23: 3248-52 (2013) Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |