Affinity DataKi: 0.0700nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 10nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 85.9nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal His-tagged human FPPS (1 to 353 residues) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before addition...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of FDPS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Allosteric inhibition of human recombinant FPPS using GPP and [3H]IPP as substrate incubated with enzyme for 10 mins prior to substrate addition by l...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate incubated for 10 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged FPPS expressed in Escherichia coli BL21 using DMAPP and IPP as substrates pretreated for 15 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of His6-tagged human truncated FPPS (6-353) expressed in Escherichia coli BL21(DE3) cells using geranyl diphosphate and isopentenyl diphos...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Binding affinity to human FPPS at 1 mM by X-ray crystallographic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) assessed as using GPP and I...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) assessed as using GPP and I...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [14C] IPP as ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP and [14C] IPP as ...More data for this Ligand-Target Pair
Affinity DataIC50: 173nMAssay Description:Competitive inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using IPP as su...More data for this Ligand-Target Pair
Affinity DataIC50: 173nMAssay Description:Competitive inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using IPP as su...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human FPPS pre-incubated for 30 mins using GPP and IPP by continuous spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of FPPS (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Competitive inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using DMAPP and...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Competitive inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using DMAPP and...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of human FPPS using IPP and GPPMore data for this Ligand-Target Pair
Affinity DataIC50: 475nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [3H]IPP and GPP as substrate measured after 10 m...More data for this Ligand-Target Pair
Affinity DataIC50: 475nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Competitive inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP as su...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Competitive inhibition of human N-terminal TEV protease cleavage site-fused-His6-tagged FPPS expressed in Escherichia coli BL21 (DE3) using GPP as su...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+5nMpH: 7.4 T: 23°CAssay Description:A biophysical assay using NMR spectroscopy to identify fragments with higher binding affinity to human recombinant FPPS.More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+8nMAssay Description:Inhibition of FPPS (unknown origin)More data for this Ligand-Target Pair
