Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dihydrofolate Reductase (DHFR) (206/206 = 100%)† (Pneumocystis carinii) | BDBM18240![]() (2,4-diamino-5-deazapteridine, 9 | Piritrexim analo...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Harvard Medical School | Assay Description Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to... | J Med Chem 48: 4420-31 (2005) Article DOI: 10.1021/jm0581718 BindingDB Entry DOI: 10.7270/Q2W0946F | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |