Affinity Data by PDB ID

PDB code 3SVG

Found 2 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bromodomain-containing protein 4 (126/127 > 99%)^† (Homo sapiens (Human))	BDBM50353596 (CHEMBL1828986) Show SMILES CCOc1cc(cc(c1)-c1c(C)noc1C)C(C)O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Displacement of H4Ac4 peptide from first bromodomain of human BRD4 by peptide displacement assay				J Med Chem 54: 6761-70 (2011) Article DOI: 10.1021/jm200640v BindingDB Entry DOI: 10.7270/Q2RV0P3P
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Bromodomain-containing protein 4 (126/127 > 99%)^† (Homo sapiens (Human))	BDBM50353596 (CHEMBL1828986) Show SMILES CCOc1cc(cc(c1)-c1c(C)noc1C)C(C)O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Binding affinity to human BRD4 bromodomain 1 using H4Ac4 peptide by amplified luminescent proximity homogeneous assay				J Med Chem 56: 3217-27 (2013) Article DOI: 10.1021/jm301588r BindingDB Entry DOI: 10.7270/Q2B859GC
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output