Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
beta-Galactosidase (β-Gal)(I51T) (653/654 > 99%)† (Homo sapiens (Human)) | BDBM50163440![]() ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) | PDB GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 4.47E+4 | -25.8 | n/a | n/a | n/a | n/a | n/a | 4.5 | 37 |
The University of Tokyo | Assay Description β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl... | J Biol Chem 289: 14560-8 (2014) Article DOI: 10.1074/jbc.M113.529529 BindingDB Entry DOI: 10.7270/Q2WH2NW4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
beta-Galactosidase (β-Gal)(R201C) (653/654 > 99%)† (Homo sapiens (Human)) | BDBM50163440![]() ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) | PDB GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 4.90E+4 | -25.6 | n/a | n/a | n/a | n/a | n/a | 4.5 | 37 |
The University of Tokyo | Assay Description β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl... | J Biol Chem 289: 14560-8 (2014) Article DOI: 10.1074/jbc.M113.529529 BindingDB Entry DOI: 10.7270/Q2WH2NW4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
beta-Galactosidase (β-Gal) (654/654 = 100%)† (Homo sapiens (Human)) | BDBM50163440![]() ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) | PDB GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 6.18E+4 | -25.0 | n/a | n/a | n/a | n/a | n/a | 4.5 | 37 |
The University of Tokyo | Assay Description β-Gal activity was measured by using 4-methylumbelliferyll-β-D-galactopyranoside in buffer B (0.15 M sodium citrate, pH 4.5, and 0.2 M NaCl... | J Biol Chem 289: 14560-8 (2014) Article DOI: 10.1074/jbc.M113.529529 BindingDB Entry DOI: 10.7270/Q2WH2NW4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Beta-galactosidase (654/654 = 100%)† (Homo sapiens (Human)) | BDBM50163440![]() ((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toyama Medical and Pharmaceutical University Curated by ChEMBL | Assay Description Inhibitory concentration against human beta-galactosidase | J Med Chem 48: 2036-44 (2005) Article DOI: 10.1021/jm0495881 BindingDB Entry DOI: 10.7270/Q2DF6S0M | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |