Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CDK2/Cyclin A/Cyclin A1 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM50088360![]() (2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATP | Bioorg Med Chem Lett 25: 3420-35 (2015) Article DOI: 10.1016/j.bmcl.2015.05.100 BindingDB Entry DOI: 10.7270/Q2736SQ1 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase 2 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM50088360![]() (2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one | 2,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Moffitt Cancer Center | Assay Description The inhibitory against activated CDK2-cyclin A2 complex was determined by using the ADP Quest fluorescence assay from (DiscoveRX, Fremont, CA) | Chembiochem 13: 2128-36 (2012) Article DOI: 10.1002/cbic.201200316 BindingDB Entry DOI: 10.7270/Q2154FN2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |