Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Competitive inhibition of human recombinant soluble epoxide hydrolase using [3H]-tDPPO as substrate | Bioorg Med Chem Lett 23: 3818-21 (2013) Article DOI: 10.1016/j.bmcl.2013.04.083 BindingDB Entry DOI: 10.7270/Q25X2BBV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay | J Med Chem 54: 3037-50 (2011) Article DOI: 10.1021/jm2001376 BindingDB Entry DOI: 10.7270/Q29W0FS2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Davis Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase | J Med Chem 50: 3825-40 (2007) Article DOI: 10.1021/jm070270t BindingDB Entry DOI: 10.7270/Q2TQ62BW | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Colorado State University Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins... | Bioorg Med Chem 20: 3255-62 (2012) Article DOI: 10.1016/j.bmc.2012.03.058 BindingDB Entry DOI: 10.7270/Q28W3FB2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of California US Patent | Assay Description See reference (Jones, P. D.; Wolf, N. M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B. D. Anal. Biochem. 343:66-75; 2005) for sEH assay. | US Patent US9029401 (2015) BindingDB Entry DOI: 10.7270/Q24Q7SR4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carb... | Bioorg Med Chem Lett 23: 3732-7 (2013) Article DOI: 10.1016/j.bmcl.2013.05.011 BindingDB Entry DOI: 10.7270/Q2057HBP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Davis Curated by ChEMBL | Assay Description Inhibition of human sEH by fluorescent assay | J Med Chem 50: 3825-40 (2007) Article DOI: 10.1021/jm070270t BindingDB Entry DOI: 10.7270/Q2TQ62BW | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
EBifunctional epoxide hydrolase 2 (555/555 = 100%)† (Homo sapiens (Human)) | BDBM50217448![]() (CHEMBL242459 | US9029401, 1471 (t-AUCB) | trans-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Davis Curated by ChEMBL | Assay Description Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus-infected High Five cells S9 fraction using CMNPC substrate by fluo... | Bioorg Med Chem Lett 28: 762-768 (2018) BindingDB Entry DOI: 10.7270/Q2PV6NZ4 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |