Affinity Data by PDB ID

PDB code 4A9L

Found 1 hit Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bromodomain-containing protein 4 (126/127 > 99%)^† (Homo sapiens (Human))	BDBM50364106 (CHEMBL1950957) Show SMILES CN1Cc2cc(ccc2N(C)C1=O)S(=O)(=O)N1CCOCC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Inhibition of His-6 tagged BRD4 expressed in Escherichia coli after 60 mins by fluorescence anisotropic analysis				J Med Chem 55: 576-86 (2012)
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output