Affinity DataKi: 1.80nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1.80nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of aurora B kinaseChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of aurora B (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:In vitro inhibition constant for Aurora-BMore data for this Ligand-Target Pair
Affinity DataKi: 18nM ΔG°: -43.8kJ/molepH: 7.5 T: 22°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMpH: 8.5 T: 22°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:In vitro kinase assay using human aurora kinase in a standard radiometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 19.8nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 7.5 T: 22°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Aurora kinase B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of human Aurora kinase B/INCEP complex expressed in Escherichia coli BL21 (DE3) using gamma-[32P]ATP incubated for 1 hr by autoradiographyMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of Aurora B in the presence of 100uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of Aurora B kinase assessed as reduction in histone H3 phosphorylation in human HCT116 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 7.40nMAssay Description:Binding constant for AURKB kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 7.40nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 7nMAssay Description:Binding affinity to Aurora B kinase catalytic domain by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 7.40nMAssay Description:Binding constant for AURKB kinase domainMore data for this Ligand-Target Pair
