Found 76 Enz. Inhib. hit(s) for PDB: 4ANS 
Affinity DataKi: 0.740nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.740nMAssay Description:Inhibition of wild type human recombinant ALK kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-CONH...More data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Inhibition of L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Inhibition of human recombinant ALK L1196M mutant kinase domain (amino acids 1093 to 1141) expressed in baculovirus system using 5'FAM-KKSRGDYMTMQIG-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: <1.20nMAssay Description:The inhibitory activities of compounds of Formula I were assay at
Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa.,
USA. Human ...More data for this Ligand-Target Pair
Affinity DataIC50: >2nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:The inhibitory activities of compounds of Formula I were assay at
Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa.,
USA. Human ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:The inhibitory activities of compounds of Formula I were assay at
Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa.,
USA. Human ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:The inhibitory activities of compounds of Formula I were assay at
Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa.,
USA. Human ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:The inhibitory activities of compounds of Formula I were assay at
Reaction Biology Corporation, One Great Valley Parkway, Malvern, Pa.,
USA. Human ...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [C1156Y](Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 7.67nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of ALK (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of ALK (unknown origin) after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 17.3nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Affinity DataIC50: 17.6nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of ALK in human KARPAS299 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of ALK by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu, Tyr)4:1 substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of purified recombinant ALK (unknown origin) after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Lactobacillus casei ATCC 7469More data for this Ligand-Target Pair
Affinity DataIC50: 36nMT: 2°CAssay Description:In order to measure the inhibitory activity against ALK, a Grainer 96-well round type bottom plate was added with the compounds (2 μl) prepared ...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:The inhibition of ALK tyrosine kinase activity can be demonstrated using known methods. For example, in one method, compounds can be tested for their...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant ALK R1275Q mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant ALK T1151M mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human wild type EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of wild type EML4/ALK (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of NPM-fused ALK phosphorylation (unknown origin) expressed in human karpas 299 cells after 90 mins by Sandwich-ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [C1156Y](Homo sapiens (Human))
Tianjin University Of Science And Technology
Tianjin University Of Science And Technology
Affinity DataIC50: 133nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Affinity DataIC50: 148nMAssay Description:Inhibition of recombinant ALK L1152R mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 165nMAssay Description:Inhibition of human EML4-fused ALK F1174L mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 165nMAssay Description:Inhibition of wild type EML4/ALK F1174L mutant (unknown origin) expressed in NIH/3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 188nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMT: 2°CAssay Description:In order to measure the inhibitory activity against ALK, a Grainer 96-well round type bottom plate was added with the compounds (2 μl) prepared ...More data for this Ligand-Target Pair
Affinity DataIC50: 337nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
Affinity DataIC50: 353nMAssay Description:Inhibition of recombinant ALK S1206Y mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 355nMAssay Description:Inhibition of recombinant ALK L1196M mutant (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 478nMAssay Description:Inhibition of human EML4-fused ALK C1156Y mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
