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Report error Found 6 Enz. Inhib. hit(s) for PDB: 4DCH
TargetHexokinase-4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50346020((2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-t...)
Affinity DataEC50:  500nMAssay Description:Activation of glucokinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161674(3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiaz...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for glucokinase activation with 15 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHexokinase-4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50346020((2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-t...)
Affinity DataKd:  500nMAssay Description:Binding affinity to recombinant wild-type human pancreatic glucokinase expressed in Escherichia coli K-12 by isothermal titration calorimetry in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHexokinase-4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50346020((2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-t...)
Affinity DataEC50:  690nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHexokinase-4(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50161674(3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiaz...)
Affinity DataEC50:  2.67E+4nMAssay Description:Activation of glucokinase (unknown origin) using glucose as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHexokinase-4(Rat)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50161674(3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiaz...)
Affinity DataEC50:  2.20E+3nMAssay Description:Effective concentration for glucokinase activation with 5 mM glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)