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Report error Found 4 Enz. Inhib. hit(s) for PDB: 4IN4
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50120421(CHEMBL2402206)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of Cys5-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50120421(CHEMBL2402206)
Affinity DataIC50:  1.18E+5nMAssay Description:Displacement of MR121-Nrf2 from human N-terminal His-tagged Kelch-DC domain of Keap1 (321 to 609) expressed in Escherichia coli BL21 (DE3) after 40 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50120421(CHEMBL2402206)
Affinity DataKd:  5.10E+4nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50120421(CHEMBL2402206)
Affinity DataEC50:  1.10E+5nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) assessed as thermal stabiliza...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)