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Report error Found 5 Enz. Inhib. hit(s) for PDB: 4ITH
LigandPNGBDBM36372((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM36372((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Affinity DataIC50:  320nMAssay Description:Inhibition of RIPK1 kinase domain (unknown origin) (1 to 312 domain) incubated for 30 mins in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM36372((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human RIP1 in human U937 cells assessed as inhibition of TNF/zVAD.fmk induced necroptosis after 24 hrs by Cell titer-Glo luminescence a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM36372((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Affinity DataIC50:  630nMAssay Description:Inhibition of Flag-tagged human RIP1 (1 to 324 residues) after 30 mins by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM36372((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Affinity DataEC50:  18nMpH: 7.3 T: 30°CAssay Description:In vitro kinase assay using RIP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)