Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (340/343 > 99%)† (Homo sapiens (Human)) | BDBM50439154![]() (CHEMBL2418761) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Aurigene Discovery Technologies Ltd Curated by ChEMBL | Assay Description Inhibition of wild type human recombinant ALK after 30 mins by TR-FRET assay | Bioorg Med Chem Lett 23: 4911-8 (2013) Article DOI: 10.1016/j.bmcl.2013.06.071 BindingDB Entry DOI: 10.7270/Q2BK1DS7 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (340/343 > 99%)† (Homo sapiens (Human)) | BDBM50439154![]() (CHEMBL2418761) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Aurigene Discovery Technologies Ltd Curated by ChEMBL | Assay Description Inhibition of ALK in human KARPAS299 cells assessed as phosphorylated ALK level after 6 hrs by Western blotting analysis | Bioorg Med Chem Lett 23: 4911-8 (2013) Article DOI: 10.1016/j.bmcl.2013.06.071 BindingDB Entry DOI: 10.7270/Q2BK1DS7 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ALK tyrosine kinase receptor (340/343 > 99%)† (Homo sapiens (Human)) | BDBM50439154![]() (CHEMBL2418761) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Aurigene Discovery Technologies Ltd Curated by ChEMBL | Assay Description Inhibition of ALK in human KARPAS299 cells assessed as phosphorylated Stat3 level after 6 hrs by Western blotting analysis | Bioorg Med Chem Lett 23: 4911-8 (2013) Article DOI: 10.1016/j.bmcl.2013.06.071 BindingDB Entry DOI: 10.7270/Q2BK1DS7 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |