Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Folate receptor beta (205/205 = 100%)† (Homo sapiens (Human)) | BDBM50027656![]() (CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of FRbeta (unknown origin) expressed in Chinese hamster D4 cells assessed as cell growth inhibition incubated up to 96 hrs by Celltiter-bl... | J Med Chem 57: 8152-66 (2014) Article DOI: 10.1021/jm501113m BindingDB Entry DOI: 10.7270/Q2F47QQS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Folate receptor beta (205/205 = 100%)† (Homo sapiens (Human)) | BDBM50027656![]() (CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Binding affinity to human FR-beta receptor expressed in Chinese hamster D4 cells assessed as antiproliferative activity measured as reduction in cell... | J Med Chem 61: 2027-2040 (2018) Article DOI: null BindingDB Entry DOI: 10.7270/Q2ST7SF1 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Folate receptor beta (205/205 = 100%)† (Homo sapiens (Human)) | BDBM50027656![]() (CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 254 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Binding affinity to human FR-beta receptor expressed in Chinese hamster D4 cells assessed as antiproliferative activity measured as reduction in cell... | J Med Chem 61: 2027-2040 (2018) Article DOI: null BindingDB Entry DOI: 10.7270/Q2ST7SF1 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Folate receptor beta (205/205 = 100%)† (Homo sapiens (Human)) | BDBM50027656![]() (CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 254 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Inhibition of FRbeta (unknown origin) expressed in Chinese hamster D4 cells assessed as cell growth inhibition incubated up to 96 hrs in presence of ... | J Med Chem 57: 8152-66 (2014) Article DOI: 10.1021/jm501113m BindingDB Entry DOI: 10.7270/Q2F47QQS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |