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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aldose reductase (AR) (315/316 > 99%)† (Homo sapiens (Human)) | BDBM104020 (MK181) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire | Assay Description The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ... | ACS Chem Biol 11: 2693-2705 (2016) | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Aldose reductase (AR) (315/316 > 99%)† (Homo sapiens (Human)) | BDBM104020 (MK181) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Academy of Sciences of the Czech Republic | Assay Description The assays were performed at 25 degrees Celsius in a 100mM sodium phosphate buffer (pH 7.0), with the AR protein amount reaching the Vmax and 0.2mM N... | ACS Chem Biol 8: 2484-92 (2013) | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
