Found 46 Enz. Inhib. hit(s) for PDB: 4LU3 TargetCarbonic anhydrase 1/12/13/14/2/3/4/5A, mitochondrial/5B, mitochondrial/6/7/9(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Compound was evaluated for the inhibition of Carbonic anhydrase (Non competitive)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 5.70nMAssay Description:Inhibition of human carbonic anhydrase-14 preincubated for 15 mins by stopped flow CO2 dehydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 41nM ΔG°: -39.2kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of recombinant human carbonic anhydrase 14 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human CA14 preincubated for 15 mins by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase14 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase-14 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of carbonic anhydrase-14 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase-14 assessed as CO2 hydration activity by stopped-flow methodMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 14 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human full length cloned transmembrane carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant CA14 after 15 mins by CO2 hydration stopped flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase 14More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant CA14 by CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant full length CA14 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human carbonic anhydrase 14 by CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human CA14 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of full length human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant CA14 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant full length CA14-mediated CO2 hydration preincubated for 15 mins by stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human CA14 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of recombinant human CA14 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataIC50: 224nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 pretreated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1/12/13/14/2/3/4/5A, mitochondrial/5B, mitochondrial/6/7/9(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of Carbonic anhydrase enzyme in rabbitsMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 14 (20 to 280 residues) expressed in Escherichia coli BL21 (DE3) in p...More data for this Ligand-Target Pair
Affinity DataKd: 2.10nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged carbonic anhydrase 14 (20 to 280 residues) expressed in Escherichia coli BL21 (DE3) asse...More data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Inhibition of human carbonic anhydrase 14 at pH7 and 37 degC by fluorescent thermal shift assayMore data for this Ligand-Target Pair
